The research goal of this laboratory is to explore molecular mechanisms that involve in tumorigenesis and to develop new anti-cancer strategy. The main research targets are YB-1 (Y-box binding protein-1), a DNA/RNA binding protein, and DDX3, a RNA helicase. Among them, it has been confirmed that YB-1 is an oncogene in various cancers and DDX3 is a tumor suppressor in liver cancer. By analyzing their interactions with microRNAs, DNA repair systems, and protein post-translational modifications, we found that YB-1 and DDX3 are involved in the regulation of diverse cellular functions and play important roles during the development of cancer. Apart from biochemical and molecular biological studies, we validate research results in combination with animal experiments to design new cancer treatment strategies.

RNA Helicase DDX3